Veteran? See how the VA covers ketamine treatment — read our guide.
Ketamine Therapy for PTSD in Jacksonville, FL
Carrying the weight of trauma affects your daily wellbeing
Ketamine therapy for PTSD in Jacksonville is available at our veteran-owned San Marco clinic for hypervigilance, flashbacks, and treatment-resistant trauma symptoms. Infusions are trauma-informed, psychiatrically supervised, and often paired with ongoing therapy support.
Conditions we treat
About this treatment
Ketamine-assisted support for PTSD in Jacksonville
Ketamine may help reduce PTSD symptoms by affecting glutamate pathways involved in trauma processing and emotional regulation. Care in San Marco is trauma-informed and veteran-aware, delivered by the same provider each session in a safe, private room — which matters more with trauma than with almost anything else. Treatment works best as part of a comprehensive plan that may include therapy — and veterans can also review our VA coverage guide.
Why patients choose us
What makes our care different
Ketamine may help reduce PTSD symptoms by affecting glutamate pathways involved in trauma processing and emotional regulation. Care in San Marco is trauma-informed and veteran-aware, delivered by the same provider each session in a safe, private room — which matters more with trauma than with almost anything else. Treatment works best as part of a comprehensive plan that may include therapy — and veterans can also review our VA coverage guide.
Personalized Approach
Every treatment plan is tailored to your unique needs, goals, and clinical profile.
A Provider Who Knows You
The same clinician evaluates you, builds your plan, and follows it — no handoffs, no re-explaining your history.
Comprehensive Evaluation
Thorough assessment to understand your complete health picture.
Ongoing Support
We provide continuous care and monitoring throughout your treatment journey.
Integrated Services
Access to multiple specialties under one roof for coordinated care.
Comfortable Environment
Our San Marco clinic is designed to be welcoming, calm, and supportive.
What to expect
Your path, step by step
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01
Book Your Consult
Choose the service that matches your goals and schedule a consultation.
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02
Meet Your Provider
Discuss your symptoms, history, and treatment options with the clinician who will actually direct your care.
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03
Receive a Personalized Plan
Your care path is tailored to your needs, eligibility, and clinical recommendations.
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04
Begin Care With Support
Move forward with a clear plan and ongoing support from the same provider who built it.
This may be a fit if you…
- Adults seeking personalized, evidence-based care
- Those looking for a comprehensive, whole-person approach
- Patients willing to engage in an initial consultation
- Individuals seeking compassionate, professional healthcare
It may not be right if you…
- Those seeking emergency or acute crisis care (please call 911)
- Individuals unable to participate in the consultation process
- Certain medical conditions may require clearance from your primary physician
What the research shows
IV infusions vs. Spravato
Systematic reviews of separate controlled trials have reported larger pooled short-term effects for IV ketamine on several measures. These are indirect comparisons — direct head-to-head evidence remains limited.
Key — how to read the numbers
- Hedges’ g
- The research score behind our “small / large improvement” labels — it measures how big the improvement was, not just whether it happened. Rough guide: ~0.2 = small, ~0.5 = medium, ~0.8 or higher = large. Higher is better.
- NNT
- Number Needed to Treat — how many people need this treatment for one extra person to improve compared with placebo. Example: NNT 3 means treat 3 people for one additional good outcome. Lower is better.
Response compared with placebo
Pooled relative likelihood of a clinically meaningful reduction in depression symptoms
3× more likely
Larger pooled relative effect
1.4× more likely
Remission compared with placebo
Pooled relative likelihood of reaching few or no remaining depression symptoms
3.7× more likely
Larger pooled relative effect
1.5× more likely
Pooled symptom improvement
How much symptoms improved on average across separate controlled trials (Hedges’ g 1.52 vs. 0.31); study designs and populations varied.
Large improvement
Larger pooled effect size
Small improvement
Number needed to treat (NNT)
Lower NNT means fewer people need treatment for one additional person to respond compared with placebo.
✓ NNT 3 from day 1 to week 1; NNT 9 at 4 weeks
— NNT 2 at day 1; NNT 11 at 4 weeks
Sources: Bahji et al. (2021) Seshadri et al. (2024) Calder et al. (2024) . Figures are relative effects versus placebo or pooled effect sizes from systematic reviews and meta-analyses of depression trials.
Individual results vary. Ketamine therapy is not appropriate for everyone — candidacy is determined during a comprehensive psychiatric evaluation.
Common questions
What patients ask about Ketamine for PTSD
How can ketamine help with PTSD symptoms in Jacksonville?
Ketamine may help reduce PTSD symptoms by affecting glutamate pathways related to trauma processing. At The Practice in Jacksonville, many patients seek care for hypervigilance, flashbacks, and treatment-resistant symptoms — including veterans exploring options beyond standard meds alone.
Is ketamine a cure for PTSD?
Ketamine is not a cure, but it may provide significant symptom relief. It is most effective as part of a comprehensive treatment plan that may include therapy and other supports.
What does a PTSD-focused session involve?
Sessions take place in a calm, private room with continuous monitoring. Your provider is trained in trauma-informed care and stays with you throughout the session — the same person every time, so you never have to re-explain your trauma history.
Can ketamine help with complex trauma?
Many patients with complex trauma histories have found ketamine helpful. A thorough consultation helps determine if it is appropriate for your specific needs.
Will I have to talk about my trauma during the session?
No. Unlike therapy, ketamine sessions do not require you to discuss traumatic experiences. The medicine works at a neurobiological level.
How is this different from EMDR or traditional therapy?
Ketamine works through neurochemical mechanisms rather than psychological processing. Many patients find it complements their ongoing therapy work.
Do you help veterans with PTSD and VA coverage questions?
Yes. We are veteran-owned. The VA more commonly covers Spravato for qualifying TRD, while IV ketamine may be authorized through Community Care in limited cases. See our ketamine and the VA guide, then book a consultation.
How is IV ketamine paid for?
Patients generally self-pay for IV ketamine because it is used off-label. We can provide a superbill if you would like to submit it to your insurance company for possible reimbursement. The VA may authorize IV ketamine through Community Care in limited cases.
How do I start ketamine for PTSD at The Practice?
Book a consultation online or call (904) 877-1100. Full details on protocols and booking are on our main ketamine infusions page.
The ketamine resource center
Keep exploring ketamine therapy
Ketamine Infusion Therapy →
The main guide to IV ketamine at The Practice — conditions, research, and booking.
Near Ponte Vedra →
Ketamine infusions for Ponte Vedra patients — ~25 min to our San Marco clinic.
Near Jacksonville Beach →
Ketamine infusions for Jacksonville Beach patients — ~25 min to our San Marco clinic.
Near Southside →
Ketamine infusions for Southside patients — ~15 min to our San Marco clinic.
Near Westside →
Ketamine infusions for Westside patients — ~20 min to our San Marco clinic.
Near Riverside / Avondale →
Ketamine infusions for Riverside / Avondale patients — ~10 min to our San Marco clinic.
Near Orange Park →
Ketamine infusions for Orange Park patients — ~25 min to our San Marco clinic.
Near Mandarin →
Ketamine infusions for Mandarin patients — ~20 min to our San Marco clinic.
Near St. Augustine →
Ketamine infusions for St. Augustine patients — ~40 min to our San Marco clinic.
Near Nocatee →
Ketamine infusions for Nocatee patients — ~30 min to our San Marco clinic.
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Ketamine for Chronic Pain →
CRPS, neuropathy, migraines, and centralized pain protocols.
Cost & Insurance →
The dedicated guide to infusion costs, insurance, and payment questions.
Infusions vs. Spravato →
How IV ketamine and the FDA-approved nasal spray compare on results and cost.
What to Expect →
Your first infusion, hour by hour — preparation, the experience, and recovery.
How It Works →
The science: the glutamate surge and the dendritic spine regrowth seen in research.
What Is Ketamine Therapy? →
The complete beginner’s guide: history, mechanism, safety, and evidence.
Veterans & the VA →
How VA coverage works for Spravato and IV ketamine, and the Community Care path.
Ketamine FAQ →
Every common question about ketamine in Jacksonville, answered in one place.
Side Effects & Safety →
What to expect: nausea, dizziness, dissociation, blood pressure — and who shouldn’t use ketamine.
The Experience →
Does ketamine get you high? Honest answers about what an infusion actually feels like.
Preparation Guide →
What to eat, what to avoid, what to bring, and how to set yourself up for the best experience.
Aftercare Guide →
First 24 hours, the week after, and how to maximize the neuroplasticity window.
Treatment Protocol →
The standard 6-infusion induction series, why a series matters, and maintenance scheduling.
Ketamine for OCD →
For obsessive-compulsive disorder: how ketamine’s glutamate mechanism may interrupt the OCD loop.
Ketamine for Bipolar Depression →
When antidepressants can’t be used — how ketamine differs for bipolar patients on mood stabilizers.
Ketamine vs. ECT →
How IV ketamine compares to electroconvulsive therapy — efficacy, side effects, and logistics.
Success Rates & Evidence →
What the research actually shows: response rates, remission rates, and what the numbers mean.
Patient Stories →
Real patient experiences with ketamine therapy at The Practice — depression, PTSD, and chronic pain.
Find out if ketamine for ptsd is right for you
Start with a consultation — in person at our San Marco clinic or via Zoom. The psychiatric provider who will direct your care reviews your history and goals himself and gives you an honest recommendation.