Veteran? See how the VA covers ketamine treatment — read our guide.
Ketamine Infusions in Jacksonville, FL
When other treatments have not brought the relief you need
Ketamine infusions in Jacksonville at The Practice offer monitored IV ketamine therapy for treatment-resistant depression, anxiety, PTSD, and related mood symptoms. Care is delivered in San Marco by board-certified psychiatric providers — with transparent package pricing from $399 per infusion and a $49 consultation (in person or Zoom) — applied toward treatment if you are a candidate, refunded if not.
About this treatment
Ketamine infusion therapy in Jacksonville
Ketamine is an FDA-approved anesthetic that, at carefully controlled sub-anesthetic IV doses, may help treatment-resistant depression, anxiety, PTSD, and certain pain conditions. At The Practice in Jacksonville, every infusion is administered by a board-certified psychiatric provider or psychiatrist in a private, continuously monitored room — not a group setting. Protocols are personalized after consultation, with published package pricing and a $49 consult.
Prefer to compare options first? Read ketamine vs. Spravato , Jacksonville pricing , or what is ketamine therapy?
Who ketamine infusions help
Ketamine therapy in Jacksonville for depression, anxiety, PTSD, and pain
Our San Marco clinic builds each protocol around the condition you are treating — not a one-size-fits-all drip. Explore the pathway that matches your situation, or start with a free consultation and we will point you honestly.
Treatment-resistant depression →
When two or more antidepressants have not brought enough relief — the most common reason people seek IV ketamine in Jacksonville.
Anxiety disorders →
Persistent anxiety, panic, and nervous-system activation that has not responded fully to standard care.
PTSD & trauma →
Trauma-informed infusion care for hypervigilance, flashbacks, and treatment-resistant PTSD symptoms — including veterans.
Chronic pain →
CRPS, neuropathy, migraines, and centralized pain with longer, pain-focused infusion protocols.
Comparing options? See IV ketamine vs. Spravato in Jacksonville, transparent cost & insurance, or our guide for veterans and the VA.
Candidacy
Who is a good candidate for ketamine therapy?
Ketamine infusion therapy is not first-line for everyone. A board-certified psychiatric provider confirms fit after reviewing your history — including medications tried, medical risks, and goals.
This may be a fit if you…
- You have tried two or more antidepressants or therapies without adequate relief
- Depression, anxiety, or PTSD still interferes with work, relationships, or daily life
- You want faster onset than traditional medications typically provide
- You can arrange a ride home after each infusion and commit to a short induction series
It may not be right if you…
- Uncontrolled high blood pressure or certain heart conditions (screened at consult)
- Active psychosis or some unstable psychiatric presentations
- Pregnancy, or a substance-use history that needs a different level of care first
- Emergency or crisis needs — call 911 or 988; this is not an ER service
Prefer the full Q&A list? Browse the ketamine FAQ or read what a ketamine infusion feels like.
Protocol
How many ketamine treatments for depression?
Most patients with depression, anxiety, or PTSD begin with an induction series of six IV infusions over about four weeks. Many notice meaningful change within the first few sessions; those who respond often continue with occasional single booster infusions to maintain benefit. Chronic-pain protocols use longer sessions and are quoted separately.
Every visit at The Practice is monitored by a board-certified psychiatric provider or psychiatrist in a private room — continuous vitals, not a group lounge.
Science background: how ketamine works · beginner overview: what is ketamine therapy?
Your path at a glance
- 01
$49 consult
In person in San Marco or via Zoom — history, goals, honest fit.
- 02
Induction series
Typically six monitored infusions over ~4 weeks for mood protocols.
- 03
Response check
We track symptoms across the series and adjust the plan with you.
- 04
Maintenance boosters
Occasional single infusions as needed — not an open-ended subscription.
Northeast Florida
Ketamine clinic in Jacksonville’s San Marco — serving the First Coast
The Practice is a veteran-owned medical clinic at 3547 Hendricks Ave in Jacksonville’s San Marco district. Patients drive in from across Duval, St. Johns, and Clay counties for monitored IV ketamine infusion therapy — including people comparing options near the Beaches, Orange Park, and St. Augustine who want psychiatric-led care and published pricing.
Looking for a ketamine clinic near you? If you can reach San Marco for a series of visits (and arrange a ride home after each infusion), we are set up for First Coast patients who want board-certified psychiatric oversight rather than a spa-style infusion room.
- San Marco
- Southside
- Jacksonville Beach
- Ponte Vedra
- Orange Park
- Fleming Island
- St. Augustine
- St. Johns
- Mandarin
- Riverside / Avondale
Call (904) 877-1100 or book a $49 consult online. LegitScript certified.
Why patients choose us
Why patients choose The Practice for ketamine infusions in Jacksonville
Ketamine is an FDA-approved anesthetic that, at carefully controlled sub-anesthetic IV doses, may help treatment-resistant depression, anxiety, PTSD, and certain pain conditions. At The Practice in Jacksonville, every infusion is administered by a board-certified psychiatric provider or psychiatrist in a private, continuously monitored room — not a group setting. Protocols are personalized after consultation, with published package pricing and a $49 consult.
Rapid Symptom Relief
Some patients report improvements within hours to days, unlike traditional medications that may take weeks.
Treatment-Resistant Cases
Designed for those who have not found adequate relief from other treatments.
Monitored Sessions
Every infusion is supervised by board-certified psychiatric providers in a controlled medical environment.
Personalized Protocols
Treatment plans are tailored to your specific symptoms, history, and clinical needs.
Multiple Applications
May help with depression, anxiety, PTSD, and certain chronic pain conditions.
Supportive Environment
Our clinic is designed to be calming, comfortable, and conducive to healing.
What the research shows
IV ketamine vs. Spravato
Systematic reviews of separate controlled trials have reported larger pooled short-term effects for IV ketamine on several measures. These are indirect comparisons — direct head-to-head evidence remains limited.
Key — how to read the numbers
- Hedges’ g
- A research score for how big the improvement was, not just whether it happened. Rough guide: ~0.2 = small, ~0.5 = medium, ~0.8 or higher = large. Higher is better.
- NNT
- Number Needed to Treat — how many people need this treatment for one extra person to improve compared with placebo. Example: NNT 3 means treat 3 people for one additional good outcome. Lower is better.
Response compared with placebo
Pooled relative likelihood of a clinically meaningful reduction in depression symptoms
3× more likely
Larger pooled relative effect
1.4× more likely
Remission compared with placebo
Pooled relative likelihood of reaching few or no remaining depression symptoms
3.7× more likely
Larger pooled relative effect
1.5× more likely
Pooled symptom improvement
Standardized effect size across separate controlled trials; study designs and populations varied.
Hedges’ g 1.52
Larger pooled effect size
Hedges’ g 0.31
Number needed to treat (NNT)
Lower NNT means fewer people need treatment for one additional person to respond compared with placebo.
✓ NNT 3 from day 1 to week 1; NNT 9 at 4 weeks
— NNT 2 at day 1; NNT 11 at 4 weeks
Sources: Bahji et al. (2021) Seshadri et al. (2024) Calder et al. (2024) . Figures are relative effects versus placebo or pooled effect sizes from systematic reviews and meta-analyses of depression trials.
Individual results vary. Ketamine therapy is not appropriate for everyone — candidacy is determined during a comprehensive psychiatric evaluation.
Invest in your mind
Ketamine infusion cost in Jacksonville — clear package pricing
Mood-protocol IV infusions from $399–$549 each. All-inclusive: provider, private room, continuous monitoring.
6-Pack Series
$479 per infusion
Most common starting protocol
- Six infusions over about 4 weeks
- Private infusion room, every visit
- Board-certified psychiatric provider
- Continuous vitals monitoring
- $420 savings off the single infusion price
10-Pack Series
$399 per infusion
Best value for extended care
- Ten infusions — induction plus maintenance
- Private infusion room, every visit
- Board-certified psychiatric provider
- Continuous vitals monitoring
- $800 savings off the 6-pack infusion price
Single Booster Infusion
$549 per infusion*
For returning patients
- One infusion at your established dose
- Private infusion room
- Board-certified psychiatric provider
- Continuous vitals monitoring
Pricing applies to ketamine infusions for depression, anxiety, and PTSD. Infusions for chronic pain are priced separately — pain protocols require nearly three times the treatment time.
Package pricing represents per-infusion cost when purchased as a series. Financing options available — ask during your consultation.
*Only clients who have already completed an induction protocol (6 infusions in 4 weeks) with The Practice may book single infusions.
See the full cost breakdown — financing, insurance & Spravato comparison →
Common questions
Ketamine infusion therapy FAQs — Jacksonville patients
What conditions can ketamine therapy help with?
Ketamine infusion therapy at The Practice may help with treatment-resistant depression, anxiety disorders, PTSD, and certain chronic pain conditions. Suitability is determined in a comprehensive consultation with our board-certified psychiatric team in Jacksonville’s San Marco.
How much do ketamine infusions cost in Jacksonville?
Mood-protocol infusions cost $399–$549 each depending on how you book: $479 per infusion in the 6-pack series ($2,874 total), $399 in the 10-pack ($3,990 total), or $549 for a single booster after induction. Prices are all-inclusive. See our ketamine cost page for financing, insurance notes, and Spravato comparison.
Does insurance cover ketamine infusions?
Usually not — IV ketamine is used off-label for mood conditions, so most plans decline it. We provide an itemized superbill for possible out-of-network reimbursement. Spravato (esketamine nasal spray) is more commonly covered; if that is your better financial path, we will say so. HSA/FSA funds and CareCredit are often used.
How many ketamine treatments for depression will I need?
Most patients begin with an induction series of six monitored IV infusions over about four weeks. Many notice change within the first few sessions. Responders often continue with occasional single booster infusions. Your exact plan is personalized at consultation.
Who is a good candidate for ketamine therapy?
Adults with depression, anxiety, or PTSD that has not responded adequately to standard treatments — and who can complete a medical evaluation and arrange a ride home after each infusion. Uncontrolled blood pressure, certain heart conditions, active psychosis, pregnancy, and some substance-use histories may exclude candidacy until cleared.
What does a ketamine infusion session feel like?
Most patients describe a relaxed, dream-like state. You remain conscious in a private, monitored room. Mild temporary dissociation can occur and typically fades within about an hour. Read our what-to-expect guide for an hour-by-hour walkthrough.
Is ketamine therapy safe?
In a monitored clinical setting with trained providers, ketamine has a strong safety profile built on decades of medical use. At The Practice every infusion is run by a board-certified psychiatric provider or psychiatrist with continuous blood pressure, heart rate, and oxygen monitoring.
How do I start ketamine therapy near me in Jacksonville?
Book a $49 consultation — online or by calling (904) 877-1100 — in person at 3547 Hendricks Ave in San Marco or via Zoom. We review your history, confirm fit, and give written pricing before any treatment series begins.
More questions answered on our full ketamine FAQ , including safety details and booking logistics.
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The ketamine resource center
Keep exploring ketamine therapy
Treatment-Resistant Depression →
When two or more antidepressants haven’t worked — what ketamine offers TRD.
Ketamine for Anxiety →
Rapid relief for persistent anxiety, panic, and nervous-system activation.
Ketamine for PTSD →
Trauma-informed infusion care for hypervigilance and flashbacks.
Ketamine for Chronic Pain →
CRPS, neuropathy, migraines, and centralized pain protocols.
Cost & Pricing →
Transparent pricing: $399–$549 per infusion, financing, and insurance notes.
Ketamine vs. Spravato →
How IV ketamine and the FDA-approved nasal spray compare on results and cost.
What to Expect →
Your first infusion, hour by hour — preparation, the experience, and recovery.
How It Works →
The science: the glutamate surge and the dendritic spine regrowth seen in research.
What Is Ketamine Therapy? →
The complete beginner’s guide: history, mechanism, safety, and evidence.
Veterans & the VA →
How VA coverage works for Spravato and IV ketamine, and the Community Care path.
Ketamine FAQ →
Every common question about ketamine in Jacksonville, answered in one place.
Book a $49 ketamine consult in Jacksonville
Start with a $49 consultation — in person at our San Marco clinic or via Zoom. If you're a candidate, the $49 is applied toward your treatment. If not, it's refunded in full.