Veteran? See how the VA covers ketamine treatment — read our guide.
Ketamine Infusions in Jacksonville, FL
When other treatments have not brought the relief you need
Ketamine infusions in Jacksonville at The Practice offer monitored IV ketamine therapy for treatment-resistant depression, anxiety, PTSD, and related mood symptoms. Care is delivered in San Marco by board-certified psychiatric providers in a private, clinically monitored setting.
Conditions we treat
About this treatment
Ketamine infusion therapy in Jacksonville
Ketamine is an FDA-approved anesthetic that, at carefully controlled sub-anesthetic IV doses, may help treatment-resistant depression, anxiety, PTSD, and certain pain conditions. At The Practice in Jacksonville, every infusion is administered by a board-certified psychiatric provider or psychiatrist in a private, continuously monitored room — not a group setting. Protocols are personalized after consultation.
Prefer to compare options first? Read infusions vs. Spravato , the dedicated cost guide , or what is ketamine therapy?
Who ketamine infusions help
Ketamine therapy in Jacksonville for depression, anxiety, PTSD, and pain
Our San Marco clinic builds each protocol around the condition you are treating — not a one-size-fits-all drip. Explore the pathway that matches your situation.
Treatment-resistant depression →
When two or more antidepressants have not brought enough relief — the most common reason people seek IV ketamine in Jacksonville.
Anxiety disorders →
Persistent anxiety, panic, and nervous-system activation that has not responded fully to standard care.
PTSD & trauma →
Trauma-informed infusion care for hypervigilance, flashbacks, and treatment-resistant PTSD symptoms — including veterans.
Chronic pain →
CRPS, neuropathy, migraines, and centralized pain with longer, pain-focused infusion protocols.
Candidacy
Who is a good candidate for ketamine therapy?
Ketamine infusion therapy is not first-line for everyone. A board-certified psychiatric provider confirms fit after reviewing your history — including medications tried, medical risks, and goals.
This may be a fit if you…
- You have tried two or more antidepressants or therapies without adequate relief
- Depression, anxiety, or PTSD still interferes with work, relationships, or daily life
- You want faster onset than traditional medications typically provide
- You can arrange a ride home after each infusion and commit to a short induction series
It may not be right if you…
- Uncontrolled high blood pressure or certain heart conditions (screened at consult)
- Active psychosis or some unstable psychiatric presentations
- Pregnancy, or a substance-use history that needs a different level of care first
- Emergency or crisis needs — call 911 or 988; this is not an ER service
Prefer the full Q&A list? Browse the ketamine FAQ or read what a ketamine infusion feels like.
Protocol
How many ketamine treatments for depression?
Most patients with depression, anxiety, or PTSD begin with an induction series of six IV infusions over about four weeks. Many notice meaningful change within the first few sessions; those who respond often continue with occasional single booster infusions to maintain benefit. Chronic-pain protocols use longer sessions and are quoted separately.
Every visit at The Practice is monitored by a board-certified psychiatric provider or psychiatrist in a private room — continuous vitals, not a group lounge.
Science background: how ketamine works · beginner overview: what is ketamine therapy?
Your path at a glance
- 01
Clinical consultation
In person in San Marco or via Zoom — history, goals, honest fit.
- 02
Induction series
Typically six monitored infusions over ~4 weeks for mood protocols.
- 03
Response check
We track symptoms across the series and adjust the plan with you.
- 04
Maintenance boosters
Occasional single infusions as needed — not an open-ended subscription.
Northeast Florida
Ketamine clinic in Jacksonville’s San Marco — serving the First Coast
The Practice is a veteran-owned medical clinic at 3547 Hendricks Ave in Jacksonville’s San Marco district. Patients drive in from across Duval, St. Johns, and Clay counties for monitored IV ketamine infusion therapy — including people comparing options near the Beaches, Orange Park, and St. Augustine who want psychiatric-led care and psychiatric oversight.
Looking for a ketamine clinic near you? If you can reach San Marco for a series of visits (and arrange a ride home after each infusion), we are set up for First Coast patients who want board-certified psychiatric oversight rather than a spa-style infusion room.
- San Marco
- Southside
- Jacksonville Beach
- Ponte Vedra
- Orange Park
- Fleming Island
- St. Augustine
- St. Johns
- Mandarin
- Riverside / Avondale
Call (904) 877-1100 or book a consultation online. LegitScript certified.
Why patients choose us
Why patients choose The Practice for ketamine infusions in Jacksonville
Ketamine is an FDA-approved anesthetic that, at carefully controlled sub-anesthetic IV doses, may help treatment-resistant depression, anxiety, PTSD, and certain pain conditions. At The Practice in Jacksonville, every infusion is administered by a board-certified psychiatric provider or psychiatrist in a private, continuously monitored room — not a group setting. Protocols are personalized after consultation.
Rapid Symptom Relief
Some patients report improvements within hours to days, unlike traditional medications that may take weeks.
Treatment-Resistant Cases
Designed for those who have not found adequate relief from other treatments.
Monitored Sessions
Every infusion is supervised by board-certified psychiatric providers in a controlled medical environment.
Personalized Protocols
Treatment plans are tailored to your specific symptoms, history, and clinical needs.
Multiple Applications
May help with depression, anxiety, PTSD, and certain chronic pain conditions.
Supportive Environment
Our clinic is designed to be calming, comfortable, and conducive to healing.
What the research shows
IV infusions vs. Spravato
Systematic reviews of separate controlled trials have reported larger pooled short-term effects for IV ketamine on several measures. These are indirect comparisons — direct head-to-head evidence remains limited.
Key — how to read the numbers
- Hedges’ g
- The research score behind our “small / large improvement” labels — it measures how big the improvement was, not just whether it happened. Rough guide: ~0.2 = small, ~0.5 = medium, ~0.8 or higher = large. Higher is better.
- NNT
- Number Needed to Treat — how many people need this treatment for one extra person to improve compared with placebo. Example: NNT 3 means treat 3 people for one additional good outcome. Lower is better.
Response compared with placebo
Pooled relative likelihood of a clinically meaningful reduction in depression symptoms
3× more likely
Larger pooled relative effect
1.4× more likely
Remission compared with placebo
Pooled relative likelihood of reaching few or no remaining depression symptoms
3.7× more likely
Larger pooled relative effect
1.5× more likely
Pooled symptom improvement
How much symptoms improved on average across separate controlled trials (Hedges’ g 1.52 vs. 0.31); study designs and populations varied.
Large improvement
Larger pooled effect size
Small improvement
Number needed to treat (NNT)
Lower NNT means fewer people need treatment for one additional person to respond compared with placebo.
✓ NNT 3 from day 1 to week 1; NNT 9 at 4 weeks
— NNT 2 at day 1; NNT 11 at 4 weeks
Sources: Bahji et al. (2021) Seshadri et al. (2024) Calder et al. (2024) . Figures are relative effects versus placebo or pooled effect sizes from systematic reviews and meta-analyses of depression trials.
Individual results vary. Ketamine therapy is not appropriate for everyone — candidacy is determined during a comprehensive psychiatric evaluation.
Common questions
Ketamine infusion therapy FAQs — Jacksonville patients
What conditions can ketamine therapy help with?
Ketamine infusion therapy at The Practice may help with treatment-resistant depression, anxiety disorders, PTSD, and certain chronic pain conditions. Suitability is determined in a comprehensive consultation with the board-certified psychiatric provider who will oversee your infusions in Jacksonville’s San Marco.
Does insurance cover ketamine infusions?
IV ketamine is used off-label for mood conditions, while Spravato (esketamine nasal spray) is FDA-approved for treatment-resistant depression. If an on-label nasal-spray option is a better fit for your situation, we will say so.
How many ketamine treatments for depression will I need?
Most patients begin with an induction series of six monitored IV infusions over about four weeks. Many notice change within the first few sessions. Responders often continue with occasional single booster infusions. Your exact plan is personalized at consultation.
Who is a good candidate for ketamine therapy?
Adults with depression, anxiety, or PTSD that has not responded adequately to standard treatments — and who can complete a medical evaluation and arrange a ride home after each infusion. Uncontrolled blood pressure, certain heart conditions, active psychosis, pregnancy, and some substance-use histories may exclude candidacy until cleared.
What does a ketamine infusion session feel like?
Most patients describe a relaxed, dream-like state. You remain conscious in a private, monitored room. Mild temporary dissociation can occur and typically fades within about an hour. Read our what-to-expect guide for an hour-by-hour walkthrough.
Is ketamine therapy safe?
In a monitored clinical setting with trained providers, ketamine has a strong safety profile built on decades of medical use. At The Practice every infusion is run by a board-certified psychiatric provider or psychiatrist with continuous blood pressure, heart rate, and oxygen monitoring.
How do I start ketamine therapy near me in Jacksonville?
Book a consultation — online or by calling (904) 877-1100 — in person at 3547 Hendricks Ave in San Marco or via Zoom. We review your history, confirm fit, and explain the treatment plan before anything begins.
More questions answered on our full ketamine FAQ , including safety details and booking logistics.
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The ketamine resource center
Keep exploring ketamine therapy
Near Ponte Vedra →
Ketamine infusions for Ponte Vedra patients — ~25 min to our San Marco clinic.
Near Jacksonville Beach →
Ketamine infusions for Jacksonville Beach patients — ~25 min to our San Marco clinic.
Near Southside →
Ketamine infusions for Southside patients — ~15 min to our San Marco clinic.
Near Westside →
Ketamine infusions for Westside patients — ~20 min to our San Marco clinic.
Near Riverside / Avondale →
Ketamine infusions for Riverside / Avondale patients — ~10 min to our San Marco clinic.
Near Orange Park →
Ketamine infusions for Orange Park patients — ~25 min to our San Marco clinic.
Near Mandarin →
Ketamine infusions for Mandarin patients — ~20 min to our San Marco clinic.
Near St. Augustine →
Ketamine infusions for St. Augustine patients — ~40 min to our San Marco clinic.
Near Nocatee →
Ketamine infusions for Nocatee patients — ~30 min to our San Marco clinic.
Treatment-Resistant Depression →
When two or more antidepressants haven’t worked — what ketamine offers TRD.
Ketamine for Anxiety →
Rapid relief for persistent anxiety, panic, and nervous-system activation.
Ketamine for PTSD →
Trauma-informed infusion care for hypervigilance and flashbacks.
Ketamine for Chronic Pain →
CRPS, neuropathy, migraines, and centralized pain protocols.
Cost & Insurance →
The dedicated guide to infusion costs, insurance, and payment questions.
Infusions vs. Spravato →
How IV ketamine and the FDA-approved nasal spray compare on results and cost.
What to Expect →
Your first infusion, hour by hour — preparation, the experience, and recovery.
How It Works →
The science: the glutamate surge and the dendritic spine regrowth seen in research.
What Is Ketamine Therapy? →
The complete beginner’s guide: history, mechanism, safety, and evidence.
Veterans & the VA →
How VA coverage works for Spravato and IV ketamine, and the Community Care path.
Ketamine FAQ →
Every common question about ketamine in Jacksonville, answered in one place.
Side Effects & Safety →
What to expect: nausea, dizziness, dissociation, blood pressure — and who shouldn’t use ketamine.
The Experience →
Does ketamine get you high? Honest answers about what an infusion actually feels like.
Preparation Guide →
What to eat, what to avoid, what to bring, and how to set yourself up for the best experience.
Aftercare Guide →
First 24 hours, the week after, and how to maximize the neuroplasticity window.
Treatment Protocol →
The standard 6-infusion induction series, why a series matters, and maintenance scheduling.
Ketamine for OCD →
For obsessive-compulsive disorder: how ketamine’s glutamate mechanism may interrupt the OCD loop.
Ketamine for Bipolar Depression →
When antidepressants can’t be used — how ketamine differs for bipolar patients on mood stabilizers.
Ketamine vs. ECT →
How IV ketamine compares to electroconvulsive therapy — efficacy, side effects, and logistics.
Success Rates & Evidence →
What the research actually shows: response rates, remission rates, and what the numbers mean.
Patient Stories →
Real patient experiences with ketamine therapy at The Practice — depression, PTSD, and chronic pain.
Book a ketamine consultation in Jacksonville
Start with a consultation — in person at our San Marco clinic or via Zoom. The psychiatric provider who will direct your care reviews your history and goals himself and gives you an honest recommendation.