Veteran? See how the VA covers ketamine treatment — read our guide.
Ketamine for Chronic Pain in Jacksonville, FL
Living with chronic pain that affects every aspect of your life
Ketamine for chronic pain in Jacksonville can help when CRPS, neuropathy, migraines, or centralized pain have not responded to standard management. Pain-focused IV protocols at The Practice in Jacksonville use longer, monitored infusions tailored after a clinical evaluation.
Conditions we treat
- Treatment-resistant depression
- Depression
- Anxiety
- PTSD
- Bipolar depression
- OCD
- Chronic pain
About this treatment
Ketamine for chronic pain in Jacksonville
Ketamine may help modulate pain signals in the central nervous system for conditions like CRPS, neuropathy, migraines, and centralized pain. Our Jacksonville pain-focused infusion protocols use longer sessions than mood protocols. Each plan follows a thorough evaluation of your pain history and medical needs at our San Marco clinic.
Why patients choose us
What makes our care different
Ketamine may help modulate pain signals in the central nervous system for conditions like CRPS, neuropathy, migraines, and centralized pain. Our Jacksonville pain-focused infusion protocols use longer sessions than mood protocols. Each plan follows a thorough evaluation of your pain history and medical needs at our San Marco clinic.
Personalized Approach
Every treatment plan is tailored to your unique needs, goals, and clinical profile.
A Provider Who Knows You
The same clinician evaluates you, builds your plan, and follows it — no handoffs, no re-explaining your history.
Comprehensive Evaluation
Thorough assessment to understand your complete health picture.
Ongoing Support
We provide continuous care and monitoring throughout your treatment journey.
Integrated Services
Access to multiple specialties under one roof for coordinated care.
Comfortable Environment
Our San Marco clinic is designed to be welcoming, calm, and supportive.
What to expect
Your path, step by step
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01
Book Your Consult
Choose the service that matches your goals and schedule a consultation.
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02
Meet Your Provider
Discuss your symptoms, history, and treatment options with the clinician who will actually direct your care.
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03
Receive a Personalized Plan
Your care path is tailored to your needs, eligibility, and clinical recommendations.
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04
Begin Care With Support
Move forward with a clear plan and ongoing support from the same provider who built it.
This may be a fit if you…
- Adults seeking personalized, evidence-based care
- Those looking for a comprehensive, whole-person approach
- Patients willing to engage in an initial consultation
- Individuals seeking compassionate, professional healthcare
It may not be right if you…
- Those seeking emergency or acute crisis care (please call 911)
- Individuals unable to participate in the consultation process
- Certain medical conditions may require clearance from your primary physician
What the research shows
IV infusions vs. Spravato
Systematic reviews of separate controlled trials have reported larger pooled short-term effects for IV ketamine on several measures. These are indirect comparisons — direct head-to-head evidence remains limited.
Key — how to read the numbers
- Hedges’ g
- The research score behind our “small / large improvement” labels — it measures how big the improvement was, not just whether it happened. Rough guide: ~0.2 = small, ~0.5 = medium, ~0.8 or higher = large. Higher is better.
- NNT
- Number Needed to Treat — how many people need this treatment for one extra person to improve compared with placebo. Example: NNT 3 means treat 3 people for one additional good outcome. Lower is better.
Response compared with placebo
Pooled relative likelihood of a clinically meaningful reduction in depression symptoms
3× more likely
Larger pooled relative effect
1.4× more likely
Remission compared with placebo
Pooled relative likelihood of reaching few or no remaining depression symptoms
3.7× more likely
Larger pooled relative effect
1.5× more likely
Pooled symptom improvement
How much symptoms improved on average across separate controlled trials (Hedges’ g 1.52 vs. 0.31); study designs and populations varied.
Large improvement
Larger pooled effect size
Small improvement
Number needed to treat (NNT)
Lower NNT means fewer people need treatment for one additional person to respond compared with placebo.
✓ NNT 3 from day 1 to week 1; NNT 9 at 4 weeks
— NNT 2 at day 1; NNT 11 at 4 weeks
Sources: Bahji et al. (2021) Seshadri et al. (2024) Calder et al. (2024) . Figures are relative effects versus placebo or pooled effect sizes from systematic reviews and meta-analyses of depression trials.
Individual results vary. Ketamine therapy is not appropriate for everyone — candidacy is determined during a comprehensive psychiatric evaluation.
Common questions
What patients ask about Ketamine for Pain
What types of pain can ketamine help with in Jacksonville?
Ketamine may help with chronic pain conditions including CRPS, neuropathy, migraines, and centralized pain. Pain protocols at The Practice use longer monitored infusions than mood protocols and are determined after a clinical evaluation.
How is ketamine for pain different from anesthesia?
Pain management ketamine uses much lower doses than anesthesia. The goal is to modulate pain signals and reduce central sensitization, not to induce unconsciousness.
What is the infusion protocol for pain?
Pain protocols typically involve a series of longer infusions. Your specific protocol is determined during consultation based on your pain condition and medical history.
Can I continue my current pain medications?
In most cases, yes. Your provider coordinates directly with your existing prescribers — one person holding the thread, so nothing is duplicated or missed.
How long do pain relief effects last?
Duration of relief varies. Some patients experience weeks to months of improvement. Maintenance infusions may be recommended to sustain results.
Is there any special preparation needed?
Preparation guidelines are provided during your consultation. You will need to arrange for someone to drive you home after infusions.
What happens during a pain infusion session?
You will relax in a private room while the infusion is administered. Your provider monitors you continuously throughout the session.
How is IV ketamine paid for?
Patients generally self-pay for IV ketamine because it is used off-label. We can provide a superbill if you would like to submit it to your insurance company for possible reimbursement. Pain protocols are determined after a clinical evaluation.
How does pain ketamine relate to your main infusion program?
Pain care uses the same San Marco clinic and psychiatric-led monitoring model as our depression and PTSD infusions, with longer protocols. See the main ketamine infusions page for clinic overview and booking.
The ketamine resource center
Keep exploring ketamine therapy
Ketamine Infusion Therapy →
The main guide to IV ketamine at The Practice — conditions, research, and booking.
Near Ponte Vedra →
Ketamine infusions for Ponte Vedra patients — ~25 min to our San Marco clinic.
Near Jacksonville Beach →
Ketamine infusions for Jacksonville Beach patients — ~25 min to our San Marco clinic.
Near Southside →
Ketamine infusions for Southside patients — ~15 min to our San Marco clinic.
Near Westside →
Ketamine infusions for Westside patients — ~20 min to our San Marco clinic.
Near Riverside / Avondale →
Ketamine infusions for Riverside / Avondale patients — ~10 min to our San Marco clinic.
Near Orange Park →
Ketamine infusions for Orange Park patients — ~25 min to our San Marco clinic.
Near Mandarin →
Ketamine infusions for Mandarin patients — ~20 min to our San Marco clinic.
Near St. Augustine →
Ketamine infusions for St. Augustine patients — ~40 min to our San Marco clinic.
Near Nocatee →
Ketamine infusions for Nocatee patients — ~30 min to our San Marco clinic.
Treatment-Resistant Depression →
When two or more antidepressants haven’t worked — what ketamine offers TRD.
Ketamine for Anxiety →
Rapid relief for persistent anxiety, panic, and nervous-system activation.
Ketamine for PTSD →
Trauma-informed infusion care for hypervigilance and flashbacks.
Cost & Insurance →
The dedicated guide to infusion costs, insurance, and payment questions.
Infusions vs. Spravato →
How IV ketamine and the FDA-approved nasal spray compare on results and cost.
What to Expect →
Your first infusion, hour by hour — preparation, the experience, and recovery.
How It Works →
The science: the glutamate surge and the dendritic spine regrowth seen in research.
What Is Ketamine Therapy? →
The complete beginner’s guide: history, mechanism, safety, and evidence.
Veterans & the VA →
How VA coverage works for Spravato and IV ketamine, and the Community Care path.
Ketamine FAQ →
Every common question about ketamine in Jacksonville, answered in one place.
Side Effects & Safety →
What to expect: nausea, dizziness, dissociation, blood pressure — and who shouldn’t use ketamine.
The Experience →
Does ketamine get you high? Honest answers about what an infusion actually feels like.
Preparation Guide →
What to eat, what to avoid, what to bring, and how to set yourself up for the best experience.
Aftercare Guide →
First 24 hours, the week after, and how to maximize the neuroplasticity window.
Treatment Protocol →
The standard 6-infusion induction series, why a series matters, and maintenance scheduling.
Ketamine for OCD →
For obsessive-compulsive disorder: how ketamine’s glutamate mechanism may interrupt the OCD loop.
Ketamine for Bipolar Depression →
When antidepressants can’t be used — how ketamine differs for bipolar patients on mood stabilizers.
Ketamine vs. ECT →
How IV ketamine compares to electroconvulsive therapy — efficacy, side effects, and logistics.
Success Rates & Evidence →
What the research actually shows: response rates, remission rates, and what the numbers mean.
Patient Stories →
Real patient experiences with ketamine therapy at The Practice — depression, PTSD, and chronic pain.
Find out if ketamine for pain is right for you
Start with a consultation — in person at our San Marco clinic or via Zoom. The psychiatric provider who will direct your care reviews your history and goals himself and gives you an honest recommendation.