Ketamine for Chronic Pain in Jacksonville, FL
Living with chronic pain that affects every aspect of your life
Chronic pain conditions like CRPS, neuropathy, and centralized pain can be debilitating. If traditional pain management has provided limited relief, ketamine infusions may offer a new pathway toward improved comfort and function.
New to ketamine? Start with our complete guideA different approach when standard care has not been enough
Chronic pain conditions like CRPS, neuropathy, and centralized pain can be debilitating. If traditional pain management has provided limited relief, ketamine infusions may offer a new pathway toward improved comfort and function.
A private sanctuary designed around your experience
At The Practice, every ketamine patient receives their own private room — not a shared space with strangers. We designed the environment deliberately, because how you feel during treatment matters.
120" projector screen
Watch YouTube, a calming playlist, a nature documentary, or nothing at all — you are in control of what is on the screen.
Completely private room
No shared spaces. No other patients in the room. Just you, in a calm, quiet environment designed for comfort.
You control the experience
Dim the lights, choose your content, adjust the atmosphere. This is your session, your way.
The difference is in the details
At many other practices
- Shared treatment room with other patients
- Given an eye mask to block out the room
- Headphones to drown out surrounding noise
- -No control over your environment
At The Practice
- Your own private room for the entire session
- 120" projector screen — watch what you want
- Full control over lighting, sound, and content
- A calming, thoughtfully designed environment
Ketamine for chronic pain management
Ketamine may help modulate pain signals in the central nervous system, making it a potential option for certain chronic pain conditions. Our pain-focused infusion protocols are designed to address conditions like CRPS, neuropathy, migraines, and centralized pain. Each treatment plan is developed after a thorough evaluation of your pain history and medical needs.
Why choose Ketamine for Pain at The Practice
Personalized Approach
Every treatment plan is tailored to your unique needs, goals, and clinical profile.
Expert Care Team
Our providers are trained in the latest evidence-based approaches to your care.
Comprehensive Evaluation
Thorough assessment to understand your complete health picture.
Ongoing Support
We provide continuous care and monitoring throughout your treatment journey.
Integrated Services
Access to multiple specialties under one roof for coordinated care.
Comfortable Environment
Our San Marco clinic is designed to be welcoming, calm, and supportive.
What to expect
Book Your $49 Consult
Choose the service that matches your goals and schedule a consultation.
Meet With Our Team
Discuss your symptoms, history, and treatment options with our clinical team.
Receive a Personalized Plan
Your care path is tailored to your needs, eligibility, and clinical recommendations.
Begin Care With Support
Move forward with a clear plan and ongoing support from The Practice team.
Book Your $49 Consult
Choose the service that matches your goals and schedule a consultation.
Meet With Our Team
Discuss your symptoms, history, and treatment options with our clinical team.
Receive a Personalized Plan
Your care path is tailored to your needs, eligibility, and clinical recommendations.
Begin Care With Support
Move forward with a clear plan and ongoing support from The Practice team.
Ready to take the next step?
Schedule a consultation to discuss your goals and learn if this service is right for you.
Is this right for you?
Who this is for
- Adults seeking personalized, evidence-based care
- Those looking for a comprehensive, whole-person approach
- Patients willing to engage in an initial consultation
- Individuals seeking compassionate, professional healthcare
Who may not be suitable
- Those seeking emergency or acute crisis care (please call 911)
- Individuals unable to participate in the consultation process
- Certain medical conditions may require clearance from your primary physician
A consultation is required to determine eligibility and develop a personalized treatment plan.
Flexible options designed to provide rapid relief and lasting change
6-Pack Series
- 6 IV infusion sessions
- Initial psychiatric evaluation
- Customized dosing protocol
- Integration support
- Priority scheduling
10-Pack Series
- 10 IV infusion sessions
- Full psychiatric evaluation
- Customized dosing protocol
- Integration support
- Priority scheduling
Single Booster Infusion
- 45-60 minute IV infusion
- Vital sign monitoring
- Private treatment room
- Post-session observation
- Board-certified provider
Package pricing represents per-infusion cost when purchased as a series. Financing options available — ask during your consultation.
*Only clients who have already completed an induction protocol (6 infusions in 4 weeks) with The Practice may book single infusions.
IV Ketamine vs. ketamine nasal spray
Across head-to-head systematic reviews and meta-analyses published between 2020 and 2024, IV ketamine consistently outperformed ketamine nasal spray on every major measure.
Chance of meaningful relief
How much more likely patients were to see their symptoms cut in half, compared to placebo
Bahji et al., J Affect Disord 2021 (RR 3.01 vs 1.38)
More than twice the benefit of the nasal spray
Chance of remission
How much more likely patients were to reach few or no remaining symptoms, compared to placebo
Bahji et al., J Affect Disord 2021 (RR 3.70 vs 1.47)
About 2.5× the benefit of the nasal spray
Size of the improvement
How much symptoms improved in head-to-head studies. Researchers consider anything above 0.8 a large effect.
Seshadri et al., J Affect Disord 2024 (Hedges' g)
Nearly five times the measured improvement
Compared to typical antidepressants
How each stacks up against everyday medications like SSRIs
Fountoulakis et al., Am J Psychiatry 2025; Nikolin et al., eClinicalMedicine 2023
Roughly double the effect of typical antidepressants
About the same as typical antidepressants
How well the benefit lasts
Whether patients were still feeling better a month after treatment
Calder et al., J Affect Disord 2024 (NNT 3→9 vs 2→11)
Benefit holds up well at 4 weeks
Strong at first, but fades faster
Relief from suicidal thoughts
How long measurable relief lasted in studies
Shen et al., Transl Psychiatry 2024; Wang et al., Clin Psychopharm Neurosci 2021
Within a day — still measurable nearly 4 weeks later
A few hours — no longer measurable by the next day
Sticking with treatment
How many patients stopped treatment early in studies
Bahji et al., J Affect Disord 2021
More patients completed treatment
80% more patients dropped out
Sources: Bahji et al., J Affect Disord 2021 · Seshadri et al., J Affect Disord 2024 · Calder et al., J Affect Disord 2024 · Nikolin et al., eClinicalMedicine 2023 · Shen et al., Transl Psychiatry 2024 · Wang et al., Clin Psychopharmacol Neurosci 2021 · Fountoulakis et al., Am J Psychiatry 2025. Figures are relative risk vs. placebo and pooled effect sizes from systematic reviews and meta-analyses of randomized trials in depression.
Individual results vary. Ketamine therapy is not appropriate for everyone — candidacy is determined during a comprehensive psychiatric evaluation.
Common questions about Ketamine for Pain
Related Services
Ready to explore your options?
A $49 consultation — learn if Ketamine for Pain is the right fit for your goals, symptoms, and care needs.