Limited-time offer: ketamine consultations are currently FREE. In person or via Zoom.
Veteran? See how the VA covers ketamine treatment — read our guide.
Ketamine for Chronic Pain in Jacksonville, FL
Living with chronic pain that affects every aspect of your life
Ketamine for chronic pain in Jacksonville can help when CRPS, neuropathy, migraines, or centralized pain have not responded to standard management. Pain-focused IV protocols at The Practice in San Marco use longer, monitored infusions tailored after a clinical evaluation.
About this treatment
Ketamine for chronic pain in Jacksonville
Ketamine may help modulate pain signals in the central nervous system for conditions like CRPS, neuropathy, migraines, and centralized pain. Our Jacksonville pain-focused infusion protocols use longer sessions than mood protocols and are priced separately. Each plan follows a thorough evaluation of your pain history and medical needs at our San Marco clinic.
Why patients choose us
What makes our care different
Ketamine may help modulate pain signals in the central nervous system for conditions like CRPS, neuropathy, migraines, and centralized pain. Our Jacksonville pain-focused infusion protocols use longer sessions than mood protocols and are priced separately. Each plan follows a thorough evaluation of your pain history and medical needs at our San Marco clinic.
Personalized Approach
Every treatment plan is tailored to your unique needs, goals, and clinical profile.
Expert Care Team
Our providers are trained in the latest evidence-based approaches to your care.
Comprehensive Evaluation
Thorough assessment to understand your complete health picture.
Ongoing Support
We provide continuous care and monitoring throughout your treatment journey.
Integrated Services
Access to multiple specialties under one roof for coordinated care.
Comfortable Environment
Our San Marco clinic is designed to be welcoming, calm, and supportive.
What to expect
Your path, step by step
-
01
Book Your Consult
Choose the service that matches your goals and schedule a consultation.
-
02
Meet With Our Team
Discuss your symptoms, history, and treatment options with our clinical team.
-
03
Receive a Personalized Plan
Your care path is tailored to your needs, eligibility, and clinical recommendations.
-
04
Begin Care With Support
Move forward with a clear plan and ongoing support from The Practice team.
This may be a fit if you…
- Adults seeking personalized, evidence-based care
- Those looking for a comprehensive, whole-person approach
- Patients willing to engage in an initial consultation
- Individuals seeking compassionate, professional healthcare
It may not be right if you…
- Those seeking emergency or acute crisis care (please call 911)
- Individuals unable to participate in the consultation process
- Certain medical conditions may require clearance from your primary physician
What the research shows
IV ketamine vs. Spravato
Systematic reviews of separate controlled trials have reported larger pooled short-term effects for IV ketamine on several measures. These are indirect comparisons — direct head-to-head evidence remains limited.
Key — how to read the numbers
- Hedges’ g
- A research score for how big the improvement was, not just whether it happened. Rough guide: ~0.2 = small, ~0.5 = medium, ~0.8 or higher = large. Higher is better.
- NNT
- Number Needed to Treat — how many people need this treatment for one extra person to improve compared with placebo. Example: NNT 3 means treat 3 people for one additional good outcome. Lower is better.
Response compared with placebo
Pooled relative likelihood of a clinically meaningful reduction in depression symptoms
3× more likely
Larger pooled relative effect
1.4× more likely
Remission compared with placebo
Pooled relative likelihood of reaching few or no remaining depression symptoms
3.7× more likely
Larger pooled relative effect
1.5× more likely
Pooled symptom improvement
Standardized effect size across separate controlled trials; study designs and populations varied.
Hedges’ g 1.52
Larger pooled effect size
Hedges’ g 0.31
Number needed to treat (NNT)
Lower NNT means fewer people need treatment for one additional person to respond compared with placebo.
✓ NNT 3 from day 1 to week 1; NNT 9 at 4 weeks
— NNT 2 at day 1; NNT 11 at 4 weeks
Sources: Bahji et al. (2021) Seshadri et al. (2024) Calder et al. (2024) . Figures are relative effects versus placebo or pooled effect sizes from systematic reviews and meta-analyses of depression trials.
Individual results vary. Ketamine therapy is not appropriate for everyone — candidacy is determined during a comprehensive psychiatric evaluation.
Invest in your mind
Ketamine infusion cost in Jacksonville — clear package pricing
Mood-protocol IV infusions from $399–$549 each. All-inclusive: provider, private room, continuous monitoring.
6-Pack Series
$479 per infusion
Most common starting protocol
- Six infusions over about 4 weeks
- Private infusion room, every visit
- Board-certified psychiatric provider
- Continuous vitals monitoring
- $420 savings off the single infusion price
10-Pack Series
$399 per infusion
Best value for extended care
- Ten infusions — induction plus maintenance
- Private infusion room, every visit
- Board-certified psychiatric provider
- Continuous vitals monitoring
- $800 savings off the 6-pack infusion price
Single Booster Infusion
$549 per infusion*
For returning patients
- One infusion at your established dose
- Private infusion room
- Board-certified psychiatric provider
- Continuous vitals monitoring
Pricing applies to ketamine infusions for depression, anxiety, and PTSD. Infusions for chronic pain are priced separately — pain protocols require nearly three times the treatment time.
Package pricing represents per-infusion cost when purchased as a series. Financing options available — ask during your consultation.
*Only clients who have already completed an induction protocol (6 infusions in 4 weeks) with The Practice may book single infusions.
See the full cost breakdown — financing, insurance & Spravato comparison →
Common questions
What patients ask about Ketamine for Pain
What types of pain can ketamine help with in Jacksonville?
Ketamine may help with chronic pain conditions including CRPS, neuropathy, migraines, and centralized pain. Pain protocols at The Practice use longer monitored infusions than mood protocols and are quoted separately at consultation.
How is ketamine for pain different from anesthesia?
Pain management ketamine uses much lower doses than anesthesia. The goal is to modulate pain signals and reduce central sensitization, not to induce unconsciousness.
What is the infusion protocol for pain?
Pain protocols typically involve a series of longer infusions. Your specific protocol is determined during consultation based on your pain condition and medical history.
Can I continue my current pain medications?
In most cases, yes. Our team works with your existing providers to coordinate care and ensure safe, complementary treatment.
How long do pain relief effects last?
Duration of relief varies. Some patients experience weeks to months of improvement. Maintenance infusions may be recommended to sustain results.
Is there any special preparation needed?
Preparation guidelines are provided during your consultation. You will need to arrange for someone to drive you home after infusions.
What happens during a pain infusion session?
You will relax in a private room while the infusion is administered. Our team monitors you continuously throughout the session.
How does pain ketamine relate to your main infusion program?
Pain care uses the same San Marco clinic and psychiatric-led monitoring model as our depression and PTSD infusions, with longer protocols. See the main ketamine infusions page for clinic overview and free consult booking.
The ketamine resource center
Keep exploring ketamine therapy
Ketamine Infusion Therapy →
The main guide to IV ketamine at The Practice — conditions, research, and booking.
Treatment-Resistant Depression →
When two or more antidepressants haven’t worked — what ketamine offers TRD.
Ketamine for Anxiety →
Rapid relief for persistent anxiety, panic, and nervous-system activation.
Ketamine for PTSD →
Trauma-informed infusion care for hypervigilance and flashbacks.
Cost & Pricing →
Transparent pricing: $399–$549 per infusion, financing, and insurance notes.
Ketamine vs. Spravato →
How IV ketamine and the FDA-approved nasal spray compare on results and cost.
What to Expect →
Your first infusion, hour by hour — preparation, the experience, and recovery.
How It Works →
The science: the glutamate surge and the dendritic spine regrowth seen in research.
What Is Ketamine Therapy? →
The complete beginner’s guide: history, mechanism, safety, and evidence.
Veterans & the VA →
How VA coverage works for Spravato and IV ketamine, and the Community Care path.
Ketamine FAQ →
Every common question about ketamine in Jacksonville, answered in one place.
Find out if ketamine for pain is right for you
For a limited time, ketamine consultations are free — in person at our San Marco clinic or via Zoom. Board-certified psychiatric providers. Honest fit, written pricing before you commit.